ââ?¬Å?Invasive giant prolactinomaââ?¬Â is a large prolactinoma (>4 cm in dimension) presenting with serum prolactin levels\r\nof >1000 ng/dL and mass related clinical symptoms. Here we report a patient with a giant prolactinoma presented\r\nwith central hypogonadism, suppressed adrenal and thyroid function, supra sellar extension, visual field impairment\r\nand high prolactin level.\r\nThe patient was treated with cabergoline, levothyroxin and prednisolone. After 18 months, tumor size markedly\r\nreduced, associated with adrenal function and visual field improvement, but central hypogonadism and secondary\r\nhypothyroidism persisted.\r\nPrevious studies showed normalization of thyrotropin secretion after treatment but it remained low in our patient\r\neven after 18 months follow up.
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